12/3/2023 0 Comments Dendrite axon synapse micrographSpine formation and correlated assembly of presynaptic and postsynaptic molecules. The study indicates that presynaptic differentiation precedes postsynaptic differentiation. The temporal order of presynaptic and postsynaptic protein accumulation after axon–dendrite contact was determined using time-lapse microscopy and retrospective immunohistochemistry. Assembly of new individual excitatory synapses: time course and temporal order of synaptic molecule recruitment. Based on time-lapse fluorescence imaging, immunocytochemistry and EM, this study indicates that the presynaptic specialization is rapidly assembled from prefabricated packets, and that these packets contain active-zone proteins and synaptic-vesicle proteins that are associated with vesicular and tubulovesicular membrane structures.įriedman, H. Assembly of presynaptic active zones from cytoplasmic transport packets. Developing corticorubral axons of the cat form synapses on filopodial dendritic protrusions. Evidence for a role of dendritic filopodia in synaptogenesis and spine formation. The dynamics of dendritic structure in developing hippocampal slices. Structure, development, and plasticity of dendritic spines. A combined Golgi-electron microscope study of pyramidal neurons. Dendritic spines: cellular specializations imparting both stability and flexibility to synaptic function. Dendritic spines: structure, dynamics and regulation. Comparison of hippocampal dendritic spines in culture and in brain. Morphological analysis of dendritic spine development in primary cultures of hippocampal neurons. Dendritic spines of CA 1 pyramidal cells in the rat hippocampus: serial electron microscopy with reference to their biophysical characteristics. Three-dimensional structure of dendritic spines and synapses in rat hippocampus (CA1) at postnatal day 15 and adult ages: implications for the maturation of synaptic physiology and long-term potentiation. Using serial section EM and three-dimensional analysis, this study showed that numerous asymmetric synapses are formed on dendritic filopodia in the developing rat hippocampus, especially during the first postnatal week. Synaptogenesis via dendritic filopodia in developing hippocampal area CA1. Synaptic activity and the construction of cortical circuits. Emergence of order in visual system development. Induction, assembly, maturation and maintenance of a postsynaptic apparatus.
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